obesity. localized adiposity, Obesity
Conditions
Interventions
Intervention 1: Overweight and Obese individuals in the intervention group received 3 capsules of 100 mg of Grape seed extract for 12 weeks. Intervention 2: Patients in the control group received a
Treatment - Drugs
Placebo
Overweight and Obese individuals in the intervention group received 3 capsules of 100 mg of Grape seed extract for 12 weeks.
Patients in the control group received a placebo capsules similar to the Grape seed extract capsule for 12 weeks.
Sponsors
Vice chancellor for research, Shahid Beheshti university of medical sciences
Drug Applied Research Center, Tabriz
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion: Aged 20-50 years; Body mass index above 25 kg/m2 Exclusion criteria include: pregnancy, lactation; Menopause in women; History of liver disease; Kidney disease; Thyroid; Celiac; Diarrhea and Acute infection; Recent surgery; Weight loss diet in 6 months ago; Use of any drugs or supplements related to weight loss; Changes in body weight over three kilograms in 2 months ago; The use of Antioxidants supplementation in 3 months ago and Use of anticoagulants such as Aspirin,Warfarin.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body mass Index. Timepoint: Before intervention, Six weeks after intervention,Twelve weeks after intervention. Method of measurement: calculating.;Weight. Timepoint: Before intervention, six weeks after intervention,Twelve weeks after intervention. Method of measurement: Seca scale.;Waist circumference. Timepoint: Before intervention, six weeks after intervention,Twelve weeks after intervention. Method of measurement: Meter.;Hip circumference. Timepoint: Before intervention, six weeks after intervention,Twelve weeks after intervention. Method of measurement: Meter.;Waist circumference to hip ratio. Timepoint: Before intervention, six weeks after intervention,Twelve weeks after intervention. Method of measurement: Calculating.;Body fat percentage. Timepoint: Before intervention, six weeks after intervention,Twelve weeks after intervention. Method of measurement: Bioelectrical Impedance Analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hs-CRP concentration. Timepoint: Before intervent, twelve weeks after intervention. Method of measurement: Enzymatic method by kit.;Serum TNF-alpha concentration. Timepoint: Before intervent, twelve weeks after intervention. Method of measurement: Enzymatic method by kit.;Serum lipids concentration. Timepoint: Before intervent, twelve weeks after intervention. Method of measurement: Enzymatic method by kit.;NPY concentration. Timepoint: Before intervent, twelve weeks after intervention. Method of measurement: Enzymatic method by kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Parandoosh
National Nutrition and Food Technology Research Institute
Outcome results
None listed