Female infertility. Female infertility?unspecified
Conditions
Interventions
Intervention 1: In the intervention group:
on 9 -8 cycle day, endometrial scratch (biopsy) by a experienced physician is performed by using a sterile Pipelle. Intervention 2: Patients in the control
Treatment - Other
In the intervention group:
on 9 -8 cycle day, endometrial scratch (biopsy) by a experienced physician is performed by using a sterile Pipelle.
Patients in the control group have received no intervention
Sponsors
Vice chancellor for research of Royan Institute
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Patients with two or more IUI cycles failures; patients with normal uterine anatomy or normal hysterosalpingography. Exclusion Criteria: The women over forty years old; uterine myoma or polyps; patients with tubal infertility; patients with severe male factor infertility; patients with moderate or severe endometriosis; Patients with a body mass index more than 30 kg/m2
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chemical pregnancy rate. Timepoint: 12 to 14 days after IUI. Method of measurement: Number and percent of positive Beta hCG test cases.;Clinical pregnancy rate. Timepoint: 5 to 6 weeks after IUI. Method of measurement: Number and percent of cases with observed gestational sac on transvaginal ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrial thickness on HCG day. Timepoint: On the day of HCG injection. Method of measurement: Endometrial thickness (mm) in transvaginal ultrasound evaluation.;Early miscarriage rate. Timepoint: The loss of a pregnancy before 12 weeks of pregnancy after intervention. Method of measurement: Number and percent of cases with bleeding and excretion gestation products (Observed no fetal heartbeat on ultrasound). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mansoureh Haghiri
Royan Institute
Outcome results
None listed