Effect of Zataria Multiflora (Shirazi Thyme) drop versus Nystatine drop on clinical signs and symptoms in patients with denture stomatitis

Effect of Zataria Multiflora (Shirazi Thyme) drop versus Nystatine drop on clinical signs and symptoms in patients with denture stomatitis: a triple blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201507259014N72

Enrollment

Registered

2015-08-01

Start date

2014-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Denture stomatitis. Other forms of stomatitis

Interventions

Intervention 1: Zataria Multiflora (Shirazi Thyme) drop 0.1%, 2.5 ml 4 times a day for 2 weeks. Intervention 2: Nystatine drop 2.5 ml 4 times a day for 2 weeks.

Treatment - Drugs

Treatment - Other

Zataria Multiflora (Shirazi Thyme) drop 0.1%, 2.5 ml 4 times a day for 2 weeks

Nystatine drop 2.5 ml 4 times a day for 2 weeks

Eligibility

Sex/Gender

All

Age

45 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: (a) affected with denture stomatitis type 2 or 3 for at least 11 years; (b) age of 45 to 80 years. Exclusion criteria: (a) sensitivity to Zataria Multiflora or Nystatine; (b) pregnancy; (c) having anemia or malnutrition; (d) having liver disorder, renal diseases, diabetes, xerostomia, hypoparathyroidism, or immunodeficiency; (e) being treated with chemotherapy, antibiotic, or anti-fungal medications.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Assessing the extent of the inflammation and the number of colonies on palate and mucosal surface of the denture stomatitis. Timepoint: before treatment and 2, 3, 4 weeks after treatment. Method of measurement: through physical examination.	—

Secondary

Measure	Time frame
Nothing. Timepoint: Nothing. Method of measurement: Nothing.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Zahra Hayati

School of Dentistry

zah.hayati@gmail.com+98 81 3838 1086

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026