The Comparison of the effects of metformin and insulin in the treatment of hyperglycemia

The Comparison of the effects of metformin and insulin in the treatment of hyperglycemia after coronary artery bypass surgery in non diabetic patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015072311399N2

Enrollment

Registered

2015-08-04

Start date

2015-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Hyperglycemia after coronary artery bypass surgery. Condition 2: Hyperglycaemia. Other functional disturbances following cardiac surgery Hyperglycaemia, unspecified

Interventions

Intervention 1: In the intervention group (1) or insulin group, patients will receive continuous insulin infusion according to the protocol of STS.After starting insulin infusion ,these patients’ bloo

Treatment - Drugs

In the intervention group (1) or insulin group, patients will receive continuous insulin infusion according to the protocol of STS.After starting insulin infusion ,these patients’ blood glucose will b

In the intervention group (2) or metformin group, the patients will receive metformin 500 mg twice a day and before the next dose of metformin, their blood glucose will be evaluated. If lactate is hig

Eligibility

Sex/Gender

All

Age

35 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Glycosylated hemoglobin less than 7%; Blood glucose above 150 mg/dl; Elective coronary artery bypass surgery; Age between 35 to 75 years old; The use of cardiopulmonary bypass; Hemodynamically stable(BP>70 mmHg and PR between 50 and 110). Exclusion criteria: History of diabetes; GFR less than 60%; life-threatening arrhythmias; Prolonged intubation; The use of inotropic agents for hemodynamic stability; Potassium level higher than 5.5 or less than 3.5 on admission in ICU; Metabolic acidosis lower than 7.25 or lactate level higher than 4.5 mg/dl or BE less than 6 mmo/L; Pao 2 less than 60 mm Hg; The patient is NPO

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Blood Suger. Timepoint: Up to 6 hours after surgery each time and then every 6 hours. Method of measurement: Glucometer device.	—

Secondary

Measure	Time frame
Lactat. Timepoint: Q 12 Hr. Method of measurement: Using of ABG machine.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbbas-Ali Ebrahimian

Semnan University of medical Sciences

aa.ebrahimian@semums.ac.irebrahimian.aa@gmail.com+98 23 3365 4191

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026