The efficacy of articaine in mental injection

Comparison of anesthetic efficacy of articaine as a primary injection between infiltration in the incisive/mental nerve region and inferior alveolar nerve block to treat mandibular premolar teeth with irreversible pulpitis: A, randomized, controlled, parallel, double blind study.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015072123278N1

Enrollment

Registered

2016-06-01

Start date

2015-08-31

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Local anesthesia. Local anaesthetics

Interventions

Intervention 1: Intervention group: IMNI: incisive/mental nerve infiltration Injection will be performed with 1.8 ml of articaine 4%with 1:100,000 epinephrine (Articadent

Dentsply Pharmaceutical, York, PA, USA) between the two mandibular premolars teeth, if the second premolar is missing the injection will be distal to the first premolar apex and if the first premolar

Dentsply Pharmaceutical, York, PA, USA) by the inferior alveolar block technique. Intervention 2: Control group: Inferior alveolar nerve block (IANB). After isolation of the teeth with cotton rolls an

Dentsply Pharmaceutical, York, PA, USA) according to malamed technique. After the anesthesia has been confirmed with EPT, the regular root canal treatment will be initiated. If moderate or severe pa

Treatment - Other

Intervention group: IMNI: incisive/mental nerve infiltration Injection will be performed with 1.8 ml of articaine 4%with 1:100,000 epinephrine (Articadent

Dentsply Pharmaceutical, York, PA, USA) by the inferior alveolar block technique.

Control group: Inferior alveolar nerve block (IANB). After isolation of the teeth with cotton rolls and drying them with gauze, fluoride gel or tooth paste will be applied to the probe tip of electri

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Healthy patients who seek treatment for mandibular premolar teeth diagnosed with irreversible pulpitis; patients who accept to sign the informed consent Exclusion criteria: Hematological and clotting disorders; neurological disorders; allergies to local; anesthetic drugs or sulfites; pregnancy at the time of the study; Younger than 18 year older than 65 year; patients with a history of significant medical conditions (American Society of Anesthesiologists class II or higher); clinically observed lesions or swellings at the injection site

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Anesthesia. Timepoint: during the root canal treatment procedure. Method of measurement: by VAS(visual analogue scale) and EPT(electric pulp tester).	—

Secondary

Measure	Time frame
The onst of the anesthesia. Timepoint: before starting the root canal treatment. Method of measurement: by EPT (electric pulp tester).;The duration of anesthesia. Timepoint: time from the confirmation of anesthesia until the anesthesia subsided or the patient start to have pain again. Method of measurement: electric pulp tester and visual analogue scale.;Pain. Timepoint: from injection through out the treatment and one week after the treatment. Method of measurement: visual analogue scale (VAS).	—

Measure

Time frame

The onst of the anesthesia. Timepoint: before starting the root canal treatment. Method of measurement: by EPT (electric pulp tester).;The duration of anesthesia. Timepoint: time from the confirmation of anesthesia until the anesthesia subsided or the patient start to have pain again. Method of measurement: electric pulp tester and visual analogue scale.;Pain. Timepoint: from injection through out the treatment and one week after the treatment. Method of measurement: visual analogue scale (VAS).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Sholeh Ghabraei

Tehran University of Medical Sciences

sholhghabraei@yahoo.com+98 21 8835 1173

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026