Anti-tuberculosis drugs-induced hepatotoxicity. Toxic liver disease
Conditions
Interventions
Intervention 1: Intervention group: 150-mg oral capsules of Milk Thistle, twice daily, for 2 weeks with standard 4-drug anti-TB therapeutic regimen including isoniazid 5 mg/kg + rifampin 10 mg/kg + et
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age = 18 years Pulmonary or outer pulmonary tuberculosis Taking first line of anti-TB drugs (Isoniazid, Rifampin and Pyrazinamide) No use of first-line anti-TB drugs within the last 8 weeks
Exclusion criteria
Exclusion criteria: Use of known hepatotoxic drugs (e.g., sodium valproate, methotrexate, sulfonamides) Regular use of acetaminophen Use of systemic glucocorticoids Use of Silymarin-containing supplements within the last 4 weeks Alcoholism Use of antioxidant agents (e.g., vitamins E and C) Having chronic hepatic or renal disease Pregnancy Lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of ALT. Timepoint: Before the intervention and 7 and 14 days after initiation of intervention. Method of measurement: blood test.;Serum level of AST. Timepoint: Before the intervention and 7 and 14 days after initiation of intervention. Method of measurement: blood test.;Serum level of ALP. Timepoint: Before the intervention and 7 and 14 days after initiation of intervention. Method of measurement: blood test.;Serum level of bilirubin(direct/total). Timepoint: Before the intervention and 7 and 14 days after initiation of intervention. Method of measurement: blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRasool Soltani
Esfahan University of Medical Sciences
Outcome results
None listed