Evaluation of The Effect of N-acetylcysteine in The Prevention of Vancomycin-Induced Renal Disorder

Evaluation of The Effect of N-acetylcysteine in The Prevention of Vancomycin-Induced Nephrotoxicity

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150721023282N3

Enrollment

Registered

2019-02-19

Start date

2017-09-23

Completion date

Unknown

Last updated

2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vancomycin-Induced Nephrotoxicity.

Interventions

Intervention 1: Intervention group: N-acetylcysteine, 600 mg, twice daily, for 10 days. Intervention 2: Control group: Without intervention.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Treatment with Vancomycin for at Least 5 Days Creatinine Clearance > 60 ml/min (Based on MDRD Formula)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum Creatinine. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Spectrophotometry.;Blood Urea Nitrogen. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Spectrophotometry.;Creatinine Clearance. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Cockroft - Gault Formula.;12-hour Urine Volume. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Urine Bag.;The number of patients with acute kidney injury. Timepoint: End of intervention. Method of measurement: counting.	—

Measure

Time frame

Serum Creatinine. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Spectrophotometry.;Blood Urea Nitrogen. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Spectrophotometry.;Creatinine Clearance. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Cockroft - Gault Formula.;12-hour Urine Volume. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Urine Bag.;The number of patients with acute kidney injury. Timepoint: End of intervention. Method of measurement: counting.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRasool Soltani

Esfahan University of Medical Sciences

soltani@pharm.mui.ac.ir+98 31 3786 5537

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026