The effectiveness of russian olive in the treatment of oral aphthae

Evaluation of the effectiveness of Elaeagnus angustifolia extract mucoadhesive buccal film in the treatment of oral recurrent aphthous ulcers: a randomized single-blind placebo-controlled clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150721023282N27

Enrollment

Registered

2024-02-17

Start date

2024-02-20

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral recurrent aphthous ulcer. K12.0

Interventions

Intervention 1: Intervention group: mucoadhesive buccal film of Elaeagnus angustifolia extract (manufactured by the faculty of Pharmacy) standardized based on total phenol count(TPC), 4 times daily fo

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age of 18 years or more Having 1 to 5 oral aphthous ulcers No more than 48 hours of aphthous occurrence Not receiving any systemic antibiotic within the last 2 weeks

Exclusion criteria

Exclusion criteria: Pregnancy Lactation Underlying disease causing oral aphthous ulcer

Design outcomes

Primary

Measure	Time frame
Oral aphthous ulcer size. Timepoint: Before the intervention, 2 and 5 days after the start of intervention. Method of measurement: Dental caliper.;Pain severity. Timepoint: Before the intervention, 2 and 5 days after the start of intervention. Method of measurement: Visual Analog Scale.	—

Secondary

Measure	Time frame
The number of cases with complete ulcer healing. Timepoint: End of ontervention (5th day). Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRasool Soltani

Esfahan University of Medical Sciences

soltani@pharm.mui.ac.ir+98 31 3792 7067

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026