Effect of arginine in diabetic foot ulcers

Evaluation of the effect of gel containing arginine-releasing chitosan nanofibers in the healing of diabetic foot ulcers: a randomized, controlled clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150721023282N16

Enrollment

Registered

2021-03-25

Start date

2021-04-21

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetic foot ulcer. Type 2 diabetes mellitus with foot ulcer

Interventions

Intervention 1: Intervention group: Chitosan gel (the amount needed to create a layer 3 mm thick on sterile gauze and placed on the wound surface, so as to cover the entire wound surface), once a day

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Grade 1 or 2 diabetic foot ulcers in one or more areas

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Ulcer reduction percentage. Timepoint: The beginning of the intervention 7 and 14 days after the intervention. Method of measurement: Ruler.	—

Secondary

Measure	Time frame
The number of cases of erythema around the ulcer. Timepoint: The beginning of the intervention 7 and 14 days after the study. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRasool Soltani

Esfahan University of Medical Sciences

soltani@pharm.mui.ac.ir+98 31 3792 7067

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026