The effectiveness of frankincense in the treatment of oral aphthae

Evaluation of the effectiveness of Boswellia serrata extract (frankincense) in the treatment of oral aphthous ulcers compared to placebo

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150721023282N10

Enrollment

Registered

2020-04-25

Start date

2016-04-20

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral aphthous ulcer. Recurrent oral aphthae

Interventions

Intervention 1: Intervention group: orally disintegrating tablets of frankincense extract (manufactured by the faculty of Pharmacy) standardized based on 5.90% w/w of 11-keto-beta-boswellic acid, 4 ti

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age of 18 years or more Having 1 to 5 oral aphthous ulcers No more than 48 hours of aphthous occurrence; Not receiving any systemic antibiotic within the last 2 weeks

Exclusion criteria

Exclusion criteria: Pregnancy Lactation Underlying disease causing oral aphthous ulcer

Design outcomes

Primary

Measure	Time frame
Oral aphthous ulcer size. Timepoint: Before the intervention, 2 and 4 days after the start of intervention. Method of measurement: Dental caliper.;Ulcer pain severity. Timepoint: Before the intervention, 2 and 4 days after the start of intervention. Method of measurement: Visual analogue scale (VAS).	—

Secondary

Measure	Time frame
The number of cases with complete ulcer healing. Timepoint: End of ontervention (4th day). Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRasool Soltani

Esfahan University of Medical Sciences

soltani@pharm.mui.ac.ir+98 31 3792 7067

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026