The effect of Dexamethasone and Morphine administration by three methods on pain control after lumbar spinal surgery

The comparison effect of Dexamethasone and Morphine administration (intravenous, intrathecal and local) in pain control following lumbar spinal surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150721023270N2

Enrollment

Registered

2018-07-12

Start date

2017-09-23

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lumbar spinal disease. Unspecified injury to lumbar spinal cord

Interventions

Intervention 1: Intervention group: Group A: Putting a surgi-cell in dura site which impregnated with 2 mg of Morphine and 0.1 mg/kg of Dexamethasone. Intervention 2: Intervention group: Group B: Inje

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients candidates for discectomy, laminectomy and fusion in more than one segment.

Exclusion criteria

Exclusion criteria: Trauma patients, tumor of the lumbar region, rheumatologic and metabolic diseases, cardiovascular disease Drug sensitivity to Morphine Addiction history Non-completion of conservative treatment Previous lumbar spine surgery BMI index at least 35 Surgical complications such as surgical site infection Hematoma, and drug side effects such as apnea

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: At 6? 12? 24? and 48 hours after surgery. Method of measurement: Visual analogues scale.	—

Secondary

Measure	Time frame
Vomiting and nausea. Timepoint: At 6? 12? 24 and 48 hours after surgery. Method of measurement: Observation.;Total amount of Morphine requirement. Timepoint: At 6? 12? 24 and 48 hours after surgery. Method of measurement: Interview with patient.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBahareh Behnam Ghader

Qazvin University of Medical Sciences

b.behnamghader6@gmail.com+98 28 3333 5800

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026