Cronary Artery Disease Three Vessel Disease. Atherosclerotic heart disease Coronary (artery): atherosclerosis
Conditions
Interventions
Intervention 1: In I group anesthesia will maintaine with 1-1.5% of volatile anesthetitc , isoflurane and sufantanil 0.1-0.3 µg/kg/h and 0.6 mg/kg/h cisatracurium. Intervention 2: In P group anesthesi
Treatment - Drugs
In I group anesthesia will maintaine with 1-1.5% of volatile anesthetitc , isoflurane and sufantanil 0.1-0.3 µg/kg/h and 0.6 mg/kg/h cisatracurium.
In P group anesthesia will maintain by continuous infusion of propofol 50-150 mg/kg/min isoflurane and sufantanil 0.1-0.3 µg/kg/h and 0.6 mg/kg/h cisatracurium.
Sponsors
Vice Chancellaor for Research of Guilan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria:72 patients 18-65 years old with ASA classII-III who undergo CABGs with cardiopulmonary bypass; All samples will take on the morning between 7:30 am to 8:30 am. Exclusion Criteria : Emergency surgery; Hepatic or Renal failure; Neurologic Disorders; Diabetes; Malignancies; BMI>38 kg/m2; Steroid therapy before operation; Chronic Drug abuse; Thyroid dysfunction and Redo operation; sever hemorrhage ; arrhythmia resistant to treatment ;time of CPB over than 100 min ; Hct<25%;prolonged intubation in ICU; use of sympathomimetic drug to treat or help IABP and weaning(epinphrine ,norepinephrine)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Cortisol Level. Timepoint: Preoperative ,cardiopulmonary Bypass,24 hour after surgery. Method of measurement: the blood cortisol level mcg/litr. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean Arterial Pressure (mmhg). Timepoint: Preoperative,During CPB and After 24 hours). Method of measurement: with monitoring of blood pressure. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAbbas Sedighinejad
Guilan University of Medical Sciences
Outcome results
None listed