sepsis. Sepsis, unspecified
Conditions
Interventions
Intervention 1: Intervention group: intravenous infusion of heparin 500 units/hr for 7 days. Intervention 2: Control group:subcutaneous injection of heparin 5000 unit 3times a day for 7 days.
Treatment - Drugs
Intervention group: intravenous infusion of heparin 500 units/hr for 7 days
Control group:subcutaneous injection of heparin 5000 unit 3times a day for 7 days
Sponsors
Vice Chancellor for research of Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: inclusion criteria: patients above 18 years old; critically ill patients with sepsis and procalcitonin above 1; patients with signed consent form exclusion criteria: pregnancy; lactation; platelets count under 30000; patients who need heparin for DVT treatment; patients who undergone transplantation; patients who receive other anticoagulants; patients with heparin-induced thrombocytopenia history; allergy to heparin; acute kidney failure and chronic kidney failure
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clotting time variation. Timepoint: before heparin initiation, day 2, day7. Method of measurement: time (sec) with ROTEM.;Plasminogen Activator Inhibitor-1 level. Timepoint: before heparin initiation, day 2, day7. Method of measurement: PAI-1 Kit.;Neutrophil Gelatinase-associated Lipocalin level. Timepoint: before heparin initiation, day 2, day7. Method of measurement: NGAL Kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU stay. Timepoint: day of discharge from ICU. Method of measurement: number of days of staying in ICU.;Mortality. Timepoint: 28 days after admission. Method of measurement: number of expired patients in first 28 days of admission. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMasoume Nouri
Tehran University of Medical Sciences
Outcome results
None listed