Schizophrenia. Schizophrenia
Conditions
Interventions
Intervention 1: Intervention group: receive olanzapin 10-25 mg/d for 3 months with vitamin D 300000 IU IM at the begining of intervention. Intervention 2: control group: receive olanzapine 10-25 mg/d
Treatment - Drugs
Intervention group: receive olanzapin 10-25 mg/d for 3 months with vitamin D 300000 IU IM at the begining of intervention.
control group: receive olanzapine 10-25 mg/d for 3 months with placebo at the beginning of intervention.
Sponsors
Vice chancer for research , Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 68 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: diagnosis of schizophrenia according to DSM-5 criteria ,age range 18-68 ,a score of at least 60 in PANSS Exclusion criteria:Mental Retardation; Organic brain disease; Parathyroid disorders; Use of Vitamin D Supplementation in recent 3 months; Pregnancy and Lactation; Vitamin D metabolism disorders; serum level of Vitamin D below 10 nmol/ml; serum level of Vitamin D over 100 nmol/ml; No interest to continue treatment; substance abuse; GFR below 60 ml/min; No response to previous treatment with Olanzapin; BMI over 30
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale(PANSS). Timepoint: Before intervention and every one month for 3 months. Method of measurement: Clinical Examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Extrapyramidal side effects. Timepoint: before intervention and every one month for 3 months. Method of measurement: clinical exam. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamidreza Jamilian
Arak University of Medical Sciences
Outcome results
None listed