Comparison of two methods of intravenous and inhalation anesthesia for spinal disc surgery

Comparison of two methods of general anesthesia using Isoflurane and Propofol for lumbar laminectomy surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015070723098N1

Enrollment

Registered

2015-10-11

Start date

2015-09-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemorrhage. During surgical operation

Interventions

Intervention 1: continuous infusion of propofol (manufactured by Fresenius Kabi Austria GmbH) at dosage of 150 µ/kg/min is used for maintenance of anesthesia after induction. Infusion is performed for

Treatment - Drugs

continuous infusion of propofol (manufactured by Fresenius Kabi Austria GmbH) at dosage of 150 µ/kg/min is used for maintenance of anesthesia after induction. Infusion is performed for once during the

Inspiration of isoflurane (manufactured by Baxter corporation USA) at dosage of 1-1.5 % Maximum Alveolar Concentration for maintenance of anesthesia after induction. Inspiration of isoflurane is perfo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: inclusion criteria: laminectomy surgery for lumbar disc herniation; ASA score = 2. exclusion criteria: Allergy to propofol; Allergy to isoflurane; Refuse patient; Coagulation disorders; History of renal disease

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Blood on gauzes. Timepoint: End of surgery. Method of measurement: 20 milliliter blood for each standard wet gauze. 50 milliliter for each long gauze.;Quality of hemorrhage. Timepoint: End of surgery. Method of measurement: Boezzart criteria.;Blood in suction buttle. Timepoint: End of surgery. Method of measurement: Volume of blood in suction bottle in milliliter.;Hematocrit of blood in surgical field. Timepoint: During surgery. Method of measurement: Laboratory measurement in percent.;Urine output. Timepoint: End of surgery. Method of measurement: Volume of liquid in urine bag in Milliliter.	—

Measure

Time frame

Blood on gauzes. Timepoint: End of surgery. Method of measurement: 20 milliliter blood for each standard wet gauze. 50 milliliter for each long gauze.;Quality of hemorrhage. Timepoint: End of surgery. Method of measurement: Boezzart criteria.;Blood in suction buttle. Timepoint: End of surgery. Method of measurement: Volume of blood in suction bottle in milliliter.;Hematocrit of blood in surgical field. Timepoint: During surgery. Method of measurement: Laboratory measurement in percent.;Urine output. Timepoint: End of surgery. Method of measurement: Volume of liquid in urine bag in Milliliter.

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Secondary

Measure	Time frame
Heart rate. Timepoint: 15 minutes after anesthesia induction. Method of measurement: Electrocardiogram monitoring (beats per minute).;Mean arterial blood pressure. Timepoint: 15 minutes after anesthesia induction. Method of measurement: Automatic noninvasive blood pressure in mmHg.;Total duration of surgery. Timepoint: end of surgery. Method of measurement: Digital timer.;Blood transfusion. Timepoint: end of surgery. Method of measurement: Number of packed cells transfused.	—

Measure

Time frame

Heart rate. Timepoint: 15 minutes after anesthesia induction. Method of measurement: Electrocardiogram monitoring (beats per minute).;Mean arterial blood pressure. Timepoint: 15 minutes after anesthesia induction. Method of measurement: Automatic noninvasive blood pressure in mmHg.;Total duration of surgery. Timepoint: end of surgery. Method of measurement: Digital timer.;Blood transfusion. Timepoint: end of surgery. Method of measurement: Number of packed cells transfused.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Shaghaghi

Tehran University of Medical Sciences

mr-shaqaqi@student.tums.ac.ir+98 21 4401 1752

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026