traumatic brain injuries. Other intracranial injuries, Intracranial injury with prolonged coma,Traumatic subarachnoid haemorrhage,Traumatic subdural haemorrhage,Diffuse brain injury,Focal brain injury,Epidural haemorrhage,
Conditions
Interventions
Intervention 1: Intervention of this research is a ventilation mode that is called Airway Pressure Release Ventilation that applied for half an hour. This is an inverse ratio mode that airway pressure
Intervention of this research is a ventilation mode that is called Airway Pressure Release Ventilation that applied for half an hour. This is an inverse ratio mode that airway pressure of patient, bet
In the control group patients are ventilated with SIMV mode for half an hour.
Sponsors
Mashhad University of Medical Sciences, research assisstance
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age between 18 and 70 years; traumatic brain injuries who are intubated and under mechanical ventilation with SIMV mode; stable hemodynamic (MAP more than 70 mm Hg for at least 30 minutes before the start of the study); Glasgow Coma Scale 10 mm Hg. Exclusion criteria: unstable hemodynamic (MAP 25 mmHg; pneumothorax
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intracranial pressure. Timepoint: Before and half an hour after the intervention. Method of measurement: Intraventricular catheter -mmHg.;Pressure of arterial oxygen. Timepoint: Before and half an hour after the intervention. Method of measurement: mmHg.;Arterial oxygen saturation. Timepoint: Before and half an hour after the intervention. Method of measurement: Pulseoxymetry- percent.;Ratio of arterial oxygen to inspired oxygen fraction. Timepoint: Before and half an hour after the intervention. Method of measurement: number. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure. Timepoint: Before and after half an hour the intervention. Method of measurement: Barometer- mmHg.;Cerebral perfusion pressure. Timepoint: Before and after half an hour the intervention. Method of measurement: Calculation formula- mmHg. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactJavad Malekzadeh
Mashhad University of Medical Sciences
Outcome results
None listed