Knee Osteoarthritis.
Conditions
Interventions
Intervention 1: Intervention group: Atorvastatin Gel prepared by researcher, Knee local use, 2 times a day for 3 months. Intervention 2: Control group: diclofenac gel 1 % (Razak) ,2 times daily, for
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Diagnosis of mild to moderate knee osteoarthritis by a rheumatologist based on cilinical symptoms and knee X-ray No other topical treatments usage at least tow weeks before the study No oral Atorvastatin usage No other systemic analgesics or anti-inflammatory usage at least tow weeks before the study Obtaining informed consent from the patients patients aged between 40 and 75 years old
Exclusion criteria
Exclusion criteria: Those who need to use other oral or intravenous analgesics Unwilling to continue or to participate in the study any further Patients with other knee joint disorders: ( Rhumatoid Arthrities, Gout, Pseudo Gout, Infected Arthrities ) Knee corticosteroid injection in the past 3 months Joint replacement Pregnancy and lactation Sensitivity to study drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: At the beginning of the study,4weeks,8weeks,12weeks after treatment. Method of measurement: WOMAC Questionnaire.;Stiffness. Timepoint: At the beginning of the study,4weeks,8weeks,12weeks after treatment. Method of measurement: WOMAC Questionnaire.;Physical Function. Timepoint: At the beginning of the study,4weeks,8weeks,12weeks after treatment. Method of measurement: WOMAC Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNiloofar Sadat Mousanejad
Islamic Azad University
Outcome results
None listed