Major Depression Disorder.
Conditions
Interventions
Intervention 1: Intervention group:This group received one zinc gluconate 25 mg capsule daily and Sertraline drug for 84 days (12 weeks). A questionnaire was used to compare patients. The Beck Depress
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Diagnosis of major depressive disorder by a psychiatrist based on DSM-IV-TR Patients aged between 18 and 55 years old Obtaining informed consent from the patients No supplements usage at least four weeks before the study Not taking any medication except for those associated with depression status Patients whose Beck test shows moderate to high depression
Exclusion criteria
Exclusion criteria: Pregnancy or lactation Severe psychotic symptoms Changing drug class Symptoms requiring hospitalization including suicidal thoughts and actions Any disease that changes the level of Homovanillic acid levels, such as thyroid disease and drug addiction Neurological diseases, Pheochromocytoma, Panic disorder, and PTSD and any internal diseases Smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemovalenic acid is one of the essential metabolites of catecholamines and is the result of the action of the enriched COMT and MAO on them. Three parts of body fluids can be local to measure HVA. These fluids include CSF, urine and plasma. Since more than 90% of the HVA produced in the brain, without appearing in the CSF, directly enters the bloodstream, and blood samples (as compared to CSF) can easily be collected. Timepoint: At the beginning of the study, the patient was examined and at the end of the study (after 12 weeks). Method of measurement: The serum HVA level was measured by the DYNEX DSX and the HVA kit of the Zelbio Company, prepared by ELISA, was used to calculate the antibody response.;Beck Depression Inventory. Timepoint: At the beginning of the study, the patient was examined and at the end of the study (after 12 weeks). Method of measurement: Beck questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean serum levels of homovanillic acid. Timepoint: At the beginning of the study, the patient was examined and at the end of the study (after 12 weeks). Method of measurement: The serum HVA level was measured by the DYNEX DSX and the HBA kit of the Zelbio Company, prepared by ELISA, was used to calculate the antibody response.;The number obtained from Beck's questionnaire. Timepoint: At the beginning of the study, the patient was examined and at the end of the study (after 12 weeks). Method of measurement: Beck questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMobina Mirhoseini
Islamic Azad University
Outcome results
None listed