Evaluating the effect of Withania Somnifera on obsession

Evaluationthe effcet of Withania somnifera’s ethanolic extract on patient’s with obsessive-compulsive disorder

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015070523079N1

Enrollment

Registered

2015-08-10

Start date

2015-02-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-compulsive disorder. Mixed obsessional thoughts and acts

Interventions

Intervention 1: Capsuls containing freeze dried ethanolic extracts of Withania somnifera, equivalant to 2 grams of Withania somnifera's roots, divided to 4 times a day ( 500 miligrams each), for 6 wee

Treatment - Drugs

Placebo

Capsuls containing freeze dried ethanolic extracts of Withania somnifera, equivalant to 2 grams of Withania somnifera's roots, divided to 4 times a day ( 500 miligrams each), for 6 weeks

Capsuls similar to the treatment group but without Withania somnifera's ethanolic extract, containing 250 miligrams of lactose, 4 times a day for 6 weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1)Diagnosis of OCD according to DSM-IV TR. 2) Treatment with SSRI drugs with adequate dose and duration. Exclusion criteria: 1) Pregnancy. 2) Lactation. 3) Comorbidity with other acute psychological disorders. 4) Drug abuse. 5) Liver and renal disorders. 6) Usage of other drugs that have an effect on OCD (Lithium, Gabapentin, Buspirone...).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Severity of OCD symptoms. Timepoint: before intervention, 6 weeks after starting the intervention. Method of measurement: Yale Brown Obsessive Compulsive Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPardis Jahanbakhsh

Mashhad University of Medical Sciences

p.jahanbakhsh@gmail.com+98 51 3843 9270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026