Effect of the extract of Rosmarinus officinalis, Zingiber officinalis and Calendula officinalis on gingivitis

Evaluation of topical formulation (mouthwash) containing Zingiber officinalis, Rosmarinus officinalis and Calendula officinalis efficiency in patients with gingivitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015070523078N1

Enrollment

Registered

2015-08-31

Start date

2015-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingivitis. Gingivitis (chronic)

Interventions

Intervention 1: Herbal mouthwash: Mouthwash formulation of Zingiber officinalis, Rosmarinus officinalis and Calendula officinalis's extract, for each patient 10 milliliters twice a day for two weeks.

Treatment - Drugs

Herbal mouthwash: Mouthwash formulation of Zingiber officinalis, Rosmarinus officinalis and Calendula officinalis's extract, for each patient 10 milliliters twice a day for two weeks.

Placebo mouthwash: Mouthwash formulation similar to treatment group, but without the extracts of Zingiber officinalis, Rosmarinus officinalis and Calendula officinalis, for each patient 10 milliliters

Positive-control: Chlorhexidine 0.2 % mouthwash, for each patient 10 milliliters twice a day for two weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with gingivitis; having at least 18 natural teeth; MGI scores between 1.3-2.75; MQH scores of at least 1.5. Exclusion criteria: requirement of antibiotic therapy for treatment of gingivitis; using antibiotics for at least 14 days before and after the study; using anti-inflammatory drugs during the study; using anticoagulation drugs during the study; using immune-suppressive drugs; advanced gum diseases; patients under 18 or over 65; Sjogren's Syndrome; orthodontic disease; pregnancy and lactation.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Modified Gingival Index (MGI). Timepoint: At the beginning of study, seventh day and fourteenth day. Method of measurement: Observation and Evaluation.	—

Secondary

Measure	Time frame
Gingival Bleeding Index (GBI). Timepoint: At the beginning of study, seventh day and fourteenth day. Method of measurement: Observation and evaluation.;Modified Quigley- Hein Plaque Index (MQH). Timepoint: At the beginning of study, seventh day and fourteenth day. Method of measurement: Observation and evaluation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaman Mahyari

Mashhad University of Medical Sciences

mahyaris891@mums.ac.ir+98 51 3882 4589

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026