Condition 1: COVID-19. Condition 2: COVID-19. U07.1: COVID-19, virus identified U07.2: COVID-19, virus not identified
Conditions
Interventions
Intervention group: Patients undergo extracorporeal blood purification on three sessions. Each session conducts in six hours per day, using hemoperfusion filters (HA280 and HA230) manufactured by the
Sponsors
Babol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with diagnosis of COVID-19 based on the clinical manifestations, lung CT-scan, testing of pharyngeal sample using real-time polymerase chain reaction and the physician´s diagnosis Patients who have partial pressure of oxygen in alveoli (PaO2) less than 60, even after different methods of oxygen-therapy Patients who have partial pressure of oxygen in alveoli to the fraction of inspired oxygen (PaO2/FiO2) less than 200 Patients who have partial pressure of carbon dioxide in alveoli (PaCo2) more than 50; PH less than 7.35; peripheral capillary oxygen saturation (SpO2) less than 88%; and no improvement has been achieved despite 48 hours of non-invasive respiratory therapy
Exclusion criteria
Exclusion criteria: Plasma platelet count less than 30000 per microliter Multiple organ dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improving the general condition of the patient. Timepoint: Before intervention and one week after the third session of hemoperfusion. Method of measurement: No need to receive any intensive respiratory care in the patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum level of interleukin- 6. Timepoint: Before the first and after the third session of hemoperfusion. Method of measurement: To test the blood sample. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMasoumeh Asgharpour
Babol University of Medical Sciences
Outcome results
None listed