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The effect of aggressive Hydration in prevention of pancreatitis

The effect of aggressive Hydration versus nonsteroidal anti-inflammatory drug therapy in prevention of post Endoscopic Retrograde Cholangiopancreatogram pancreatitis: a double blind randomized clinical trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015070323026N1
Enrollment
186
Registered
2015-07-31
Start date
2015-01-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post ERCP pancreatitis. Other acute pancreatitis

Interventions

Intervention 1: Group 1: Solution ringer lactate bolus 20 cc/kg then 3 cc/kg/h for 8 hours. Intervention 2: Group 2: Indomethacin rectally every 12 hours for 24 hours. Intervention 3: Group 3: Placebo
Treatment - Drugs
Placebo
Group 1: Solution ringer lactate bolus 20 cc/kg then 3 cc/kg/h for 8 hours.
Group 2: Indomethacin rectally every 12 hours for 24 hours
Group 3: Placebo

Sponsors

Ahvaz Jundishapur University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: hospitalized patients who underwent Endoscopic Retrograde Cholangiopancreatography (ERCP) Exclusion criteria: acute cholongitis; sepsis; chronic pancreatitis; acute pancreatitis due to gallstones; patients at risk of increasing fluid volume; pregnant women; patient undergoing papilla dilatation; history of pancreatitis after ERCP; patients with stent embedded in pancreatic duct.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pancreatitis. Timepoint: 8 hours and 24 hours after ERCP procedure. Method of measurement: Abdominal pain plus amylase level over 270 IU/dl.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZeinab Shajirat

Ahvaz Jundishapur University of Medical Sciences

zeinab.shajirat@gmail.com+98 936 491 6479

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026