Effects of mirtazapine on serum levels of histamin and serotonin

Evaluation of the effects of mirtazapin on serum levels of histamin and serotonin in hemodialysis Patients suffering from uremic pruritus

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150629022965N18

Enrollment

Registered

2018-08-04

Start date

2018-05-22

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease. Chronic kidney disease (CKD)

Interventions

Intervention group: mirtazapine, 7.5 mg/day, for 14 days.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: aged above 18 diagnosis of end stage renal disease receiving dialysis 3 times a week no history of dermatological disorder which result in feeling itch no history allergen medications or foods no history of receiving medication which relieve itch presence of moderate, severe and very severe pruritus

Exclusion criteria

Exclusion criteria: pregnancy or lactation presence of liver failure presence of any psychiatric disorder Hyperphosphatemia diabetic neuropathy

Design outcomes

Primary

Measure	Time frame
Serum level of histamine. Timepoint: at baseline and 14 days later. Method of measurement: ELISA kit.;Serum level of serotonin. Timepoint: at baseline and 14 days later. Method of measurement: ELISA kit.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Mehrpooya

Hamedan University of Medical Sciences

m_mehrpooya2003@yahoo.com+98 81 3838 0717

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026