Effect of simvastatin on anxiety

Evaluation of anxiolytic effects of oral simvastatin as adjunat therapy in patients with general anxiety disorder

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150629022965N15

Enrollment

Registered

2018-04-24

Start date

2017-11-16

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anxiety. Generalized anxiety disorder

Interventions

Intervention 1: 20 mg/day (once daily) Simvastatin as tablet purchased from Pursina, Iran will be administrated for patients adjunct to their standard treatment for 8 weeks. Intervention 2: Matching p

Eligibility

Sex/Gender

All

Age

16 Years to 65 Years

Inclusion criteria

Inclusion criteria: Aged between 16 to 65 Patients diagnosed with general anxiety disorder based on DSM-5 and Hamilton rating score above 17 Patients without any psychiatric comorbidity such as major depressive disorder and psychosis

Exclusion criteria

Exclusion criteria: Patients receiving drugs or supplements with anti-oxidant and anti-inflammatory properties within the last month before the study Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
Severity of anxiety. Timepoint: at baseline, at 4th week of study and at the end of study. Method of measurement: Hamilton anxiety rating scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Mehrpooya

Hamedan University of Medical Sciences

m_mehrpooya2003@yahoo.com+98 81 3838 0717

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026