Condition 1: Obesity. Condition 2: Type 2 diabetes mellitus. ???? ? ?????? ???? ?? ???? Non-insulin-dependent diabetes mellitus
Conditions
Interventions
Intervention 1: Intervention: Green tea extraction capsule(no.F.P. 28) was deposited in the herbarium of faculty of pharmacy Shahid Beheshtei University of medical sciences, Tehran, Iran.
The 0.5 gra
Treatment - Drugs
Placebo
Intervention: Green tea extraction capsule(no.F.P. 28) was deposited in the herbarium of faculty of pharmacy Shahid Beheshtei University of medical sciences, Tehran, Iran.
The 0.5 gram green tea ext
Controls: microcristalin 0.5 gram placebo capsule/ three times a day for 8 weeks after each meal with the same order with drug
Sponsors
Vise Chancellor for Reseach, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age from 40 to 65 years; at least 2 years diagnosis of T2DM; BMI =25 kg/m2 (over weight and obese); completion of the informed written consent Exclusion criteria: The history of diabetic ketoacidosis, acute presentation and heavy ketonuria; History of the major comorbid conditions include cardiovascular, Liver, Renal and malabsorption diseases; Patients with history of the tea green tea allergy; Requirement of insulin within 1 year of diagnosis.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum visfatin concentration. Timepoint: Before and 8 weeks after study. Method of measurement: Elisa.;Serum Adiponestin concentration. Timepoint: Before and 8 week after the study. Method of measurement: Elisa. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum insulin concentration. Timepoint: Before and 8 week after study. Method of measurement: ELISA.;Fasting blood sugar. Timepoint: Before and 8 week after study. Method of measurement: GOD/PAP method.;Serum triglyceride concentration. Timepoint: Before and 8 week after study. Method of measurement: GPO-PAP method.;Serum total cholestrol. Timepoint: Before and 8 week after study. Method of measurement: enzymatic Endpoint method.;High density lipoprotein cholesterol (HDL-C). Timepoint: Before and 8 week after study. Method of measurement: enzymatic clearance assay.;Low-density lipoprotein-cholesterol (LDL-C). Timepoint: Before and 8 week after study. Method of measurement: enzymatic clearance assay.;Two hour postprandial blood sugar (2h PPBS). Timepoint: Before and 8 week after study. Method of measurement: GOD/PAP method.;Serum high sensitive C-reactive protein (hsCRP). Timepoint: Before and 8 week after study. Method of measurement: immune-turbidimetric assay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDoctor Somayeh Mohammadi
Faculty of Nutrition sciences and diet therapy
Outcome results
None listed