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The effect of exercise on main iron regulator hormone in patients with Beta Thalassemia Intermedia

The effect of one session of Aerobic Discontinuous Training protocol on Hepcidin and plasma Ferritin in patients with Beta Thalassemia Intermedia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015062516211N2
Enrollment
Unknown
Registered
2015-07-11
Start date
2015-07-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Beta Thalassemia Intermedia. Beta thalassaemia

Interventions

Intervention 1: Control Group will be among those who did not have regular physical activity in the past six months. Intervention 2: The exercise group after the 10-minute warm-up in three 10-minute p
Rehabilitation
Control Group will be among those who did not have regular physical activity in the past six months.
The exercise group after the 10-minute warm-up in three 10-minute periods with 65% heart rate reserve run on the treadmill. Before and after each 10-minute period RPE is measured by using the Borg ind

Sponsors

Exercise Physiology Research Center,Baqiyatallah University of Medical Sciences Baqiyatallah
Lead Sponsor

Eligibility

Sex/Gender
All
Age
31 Years to 48 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1-Patients with Beta Thalassemia Intermedia. 2-Irregular blood transfusions or no blood transfusions. 3-Ejection Fraction more than 55%. 4-Pulmonary artery pressure or (PAP) less than of 30 mm Hg. 5-Lack of Hemochromatosis. 6-The absence of fractures in lower limbs. 7-Lack of diabetes. Exclusion criteria: 1-Regular blood transfusions. 2-Iron overload in the heart. 3-Splenectomized patients. 4-Drugs such as Digoxin and other drugs associated with heart disease. 5-Personal desire, nausea, vomiting and headache during exercise.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Hepcidin. Timepoint: Before, immediately after and 3 hours after the intervention. Method of measurement: Blood sample and ELISA method.;Ferritin. Timepoint: Before, immediately after and 3 hours after the intervention. Method of measurement: Blood sample and Photometric method.—

Secondary

MeasureTime frame
24-hour dietary recall. Timepoint: 24 hour before primary blood sample. Method of measurement: By 24-hour dietary recall questionnaire.;Blood pressure. Timepoint: Before and after each period of practice. Method of measurement: By manual manometer and according to mm Hg.;RPE or Rate of Perception Effort. Timepoint: Before and after each period of practice. Method of measurement: 20-point Borg questionnaire.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactVahid Sobhani

Baqiyatallah University of Medical Sciences,Exercise Physiology Research Center

Sobhani518@yahoo.com+98 21 8248 2391

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026