Obsessive compulsive disorder. Obsessive compulsive disorder
Conditions
Interventions
Intervention 1: Tablet Buprenorphine 250 mg would be prescribed daily for 8 weeks and increased 500mg weekly with respect to patient tolerance. Intervention 2: The regular treatment is to start with a
Treatment - Drugs
Tablet Buprenorphine 250 mg would be prescribed daily for 8 weeks and increased 500mg weekly with respect to patient tolerance
The regular treatment is to start with an SSRI (Selective Serotonin Reuptake Inhibitors) or clomipramine for 4 to 6 weeks . If treatment with clomipramine or an SSRI Is unsuccessful, many therapists
Sponsors
Vice chancellor of research of Hamadan university of medical scienses
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (a) patients with primary Obsessive Compulsive Disorder who received minimum of 2 different Selective Serotonin Reuptake Inhibitor for a period of 16 weeks in two separate rotations but failed to respond to treatment (less than 25% in symptom regression); (b)age between 18 to 60 years old; (c) scores of more than 16 according to Yale-Brown Obsessive Compulsive Scale (Y-COBS) Exclusion criteria: (a) receiving any other opioid medications; (b) having any history of alcohol or substance abuse; (c) received any electroconvulsive therapy during the last two months; (d) having any serious diseases which require long term medical treatment such as diabetes, high blood pressure, rheumatoid arthritis, cardiovascular diseases, respiratory diseases, thyroid diseases or gastrointestinal diseases; (e) any signs of psychotic disorders, such as bi-polar schizophrenia or similar; (f)being at a great risk of suicide attempt; (g) any pregnant woman or any woman who intend pregnancy during the next 3 months; (h) any serious- non psychological diseases; (i)any upcoming surgery which needs anesthesia or deep Sedation; (j) patient is a candidate to receive electroconvulsive therapy.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Obsessive Compulsive Disorder severity. Timepoint: before intervention and end of 1,2,3,4,5 weeks after that. Method of measurement: Yale Brown Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Amin Reihani
Hamadan University of Medical Sciences
Outcome results
None listed