effect of VitD3 on Kidney and Muscle in Sepsis

Effect of single dose Vitamin D3 Injection on Kidney Function and Muscle Mass in Sepsis Patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150621022852N3

Enrollment

Registered

2018-11-29

Start date

2016-11-01

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis.

Interventions

Intervention 1: Intervention group: 24 patients who recieved single dose 300,000 IU vit D3 IM. Intervention 2: Control group: 22 patients who recieved placebo (1 cc Normal Saline).

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Critically ill patients within 24 hours of new-onset sepsis Had three out out of four criteria used to explain the systemic inflammatory response syndrome Were expected to stay in the ICU for at least 48 hours

Exclusion criteria

Exclusion criteria: Acute Kidney Injury At least two risk factors for AKI Rapidly changing GFR Rapidly changing serum creatinine Rapidly changing cystatin C Pregnancy History of organ transplantation Hypercalcemic (ionized calcium>1.3 mmol/L) Maintenance renal replacement therapy Platelets 3 (Coagulopathy)

Design outcomes

Primary

Measure	Time frame
Sarcopenic index. Timepoint: before the intervention, 14, 21 days after intervention. Method of measurement: serum creatinine-to-serum cystatin C ratio ×100.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Hajiesmaeili

Shahid Beheshti University of Medical Sciences

m.hajiesmaeili2018@gmail.com+98 21 5541 0044

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026