Acne vulgaris. Acne vulgaris
Conditions
Interventions
Intervention 1: Prescription of low dose of oral isotretinoin in intervention group
(0.25 mg/kg/day) six months. Intervention 2: prescription of traditional dose of oral isotretinoin (0.5 mg/kg/day)
Treatment - Drugs
Prescription of low dose of oral isotretinoin in intervention group
(0.25 mg/kg/day) six months
prescription of traditional dose of oral isotretinoin (0.5 mg/kg/day) six months
Sponsors
Vice chancellor for research of Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Absence of hypersensitivity to Retinoid; Absence of pregnancy or plan of pregnancy; no history of hormonal abnormality exclusion criteria: impossible to follow up; use of another treatment
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantity of skin lesions of acne vulgaris. Timepoint: At first and six months after initiation of treatment and six months after cessation of treatment. Method of measurement: Computation of lesions and utilization of global acne grading system. | — |
Secondary
| Measure | Time frame |
|---|---|
| Increase of liver enzymes and increase of serum lipid profile. Timepoint: At first and one and two and four and six months after initiation of treatment. Method of measurement: Transmission of blood sample to medical laboratory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Nasrin Motamedi Fard
Isfahan University Of Medical Science
Outcome results
None listed