Heart Failure. Systolic (congestive) heart failure
Conditions
Interventions
Intervention 1: Intervention group: 40 mg intravenous furosemide determined by amount of congestion. In addition, patients will receive 10 mg oral Dapagliflozin daily for 5 days (Kimia Pharmaceutical
Sponsors
Semnan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: Acute heart failure BNP>100 pg/ml receiving IV furosemide Evidence of congestion
Exclusion criteria
Exclusion criteria: Serum glucose < 80 mg/dL Type 1 diabetes mellitus Systolic blood pressure < 90 mmHg Requirement of inotropic therapy hypersensitivity to SGLT-2 inhibitors Already receiving an SGLT2 inhibitor Pregnancy History of DKA Acute MI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ejection fraction. Timepoint: At admission and 5 days after receiving the medications and at study termination. Method of measurement: echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum level of Sirtuin-1. Timepoint: At admission and 5 days after receiving the medications. Method of measurement: ELISA.;Worsening of clinical conditions. Timepoint: At release till 8 weeks. Method of measurement: Readmission and phone call. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHooman Bakhshande
ShaRajaie Cardiovascular, Medical & Research Center
Outcome results
None listed