Chronic rhinosinusitis with nasal polyposis. Other polyp of sinus Polyp of sinus: accessory ethmoidal maxillary sphenoida
Conditions
Interventions
Intervention 1: Intervention group1: aspirin desensitization and then perscription of aspirin with a daily dose of 325milligrams added to conventional treatment including intranasal beclomethasone one
Treatment - Drugs
Intervention group1: aspirin desensitization and then perscription of aspirin with a daily dose of 325milligrams added to conventional treatment including intranasal beclomethasone one puff per nostri
Intervention group 2: Aspirin desensitization and then perscription of aspirin with a daily dose of 100 milligram added to conventional treatment including intranasal beclomethasone one puff per nostr
Control: Aspirin desensitization and then perscription of placcebo tablet once daily, for which the composition is the same as Aspirin tablet except for active aspirin material, added to conventional
Sponsors
Vice chancellor for research, Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
17 Years to 64 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age of 18-65 years; achieving a course of three months of conventional treatment before aspirin challenge; presence of symptoms of chronic rhinosinusitis with nasal polyposis confirmed by CT scan; Exclusion criteria: presence of any serious underlying disease including hemorrhagic; gastrointestinal; rheumatologic; malignant; cardiovascular; renal; hepatic and psychological disorders; history of IgE mediated reactions to aspirin or other non steroidal anti inflammatory drugs; first second expiratory volume of less than 70 percent of predicted at the time of aspirin challenge; pregnancy; nursing; use of topical or systemic beta blockers; warfarin and its derivates; Angiotensin converting enzyme inhibitors; patients with poor cooperation or treatment adherence; patients with carriers with high risk of trauma and accidents;
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of symptoms of chronic rhinosinusitis with nasal polyposis. Timepoint: before intervention, three months and six minths after intervention. Method of measurement: SinoNasal Outcome Test questionnaire and paranasa sinus CT scan. | — |
Secondary
| Measure | Time frame |
|---|---|
| Complications of aspirin including gastrointestinal dyscomfort, epigastric pain or burning, nausea, vomitting, gastro intestinal bleeding, easy bruising, bleeding with minor trauma. Timepoint: before intervention, three and six months after intervention. Method of measurement: history taking and physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSima Shokri
Iran University of Medical Sciences
Outcome results
None listed