Evaluating the effect of low-level laser versus ozone in patients with Medication-related osteonecrosis of the jaw who were treated with debridement surgery and Platelet-rich fibrin

Evaluating the complementary treatment effect of low-level laser versus ozone in patients with MRONJ (Medication-related osteonecrosis of the jaw) who were treated with debridement surgery and PRF (Platelet-rich fibrin)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150613022697N13

Enrollment

Registered

2023-03-05

Start date

2023-04-04

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Osteonecrosis. Condition 2: Pain in jaw. Condition 3: Soft tissue dehiscence. Osteonecrosis due to drugs Disease of jaws, unspecified Soft tissue disorder, unspecified

Interventions

Intervention 1: Control group: Patients receive the usual and standard debridement surgery along with PRF (Platelet-rich fibrin). Intervention 2: Intervention group 1: In patients who have been treate

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: All patients with Medication-related osteonecrosis of the jaw, MRONJ stage 2, with pain and pus discharge No history of previous MRONJ treatment Absence of pathological fracture during study entry

Exclusion criteria

Exclusion criteria: Pregnant patients The impossibility of frequent visits for complementary treatment sessions (ozone or laser) Radiotherapy during the treatment process Occurrence of pathological fracture in the jaw in the affected area Dissatisfaction with continuing the study

Design outcomes

Primary

Measure	Time frame
Amount of jaw pain in the specified time period. Timepoint: 1, 3, 6 and 12 months after the intervention. Method of measurement: Visual Analogue Scale (VAS) in checklist.;Soft tissue healing. Timepoint: 1, 3, 6 and 12 months after the intervention. Method of measurement: Appropriate soft tissue healing was defined when no dehiscence occurred.	—

Secondary

Measure	Time frame
Infection. Timepoint: 1, 3, 6 and 12 months after the intervention. Method of measurement: Any sign of pus or fistula tract in treatment area.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahand Samieerad

Mashhad University of Medical Sciences

samieerads@mums.ac.ir+98 51 3882 9501

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026