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Evaluating the effect of Tizanidine on pain following orthognathic surgery.

Evaluating the effect of pre-operative administering of oral Tizanidine on the pain amount following orthognathic surgery.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20150613022697N10
Enrollment
60
Registered
2020-12-05
Start date
2020-11-20
Completion date
Unknown
Last updated
2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain in jaws. Disease of jaws, unspecified

Interventions

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Patients suffering from skeletal class 3 deformity, requiring advancement of the maxilla and set back of mandible using Lefort 1 and BSSO (Bilateral Sagittal Split Osteotomy ) technique respectively. Patients between 18 to 40 years old. Patients who completed the informed consent. Patients who are categorized in the 1st and 2nd group according to the ASA (American Society of Anesthesiology ) BMI index less than 30kg/m2

Exclusion criteria

Exclusion criteria: Patients with a history of using analgesics or psychiatric medication during the previous month. Patients with a history of addiction or psychological problems . Patients with a history of drug allergy. Patients with a history of chronic pain Patients with a history of low blood pressure and bradycardia Patients with a history of using ciprofloxacin and Fluoxetine Patients who want to leave the trial by any reason

Design outcomes

Primary

MeasureTime frame
Amount of pain in the specified time period. Timepoint: 1 ,3 ,6 , 12 , 18 ,and 24 hours after the surgery. Method of measurement: Visual Analogue Scale (VAS).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahand Samieerad

Mashhad University of Medical Sciences

samieerads@mums.ac.ir+98 51 3882 9501

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026