Burn injury. Burn and corrosion, body region unspecified
Conditions
Interventions
Intervention 1: Intervention group1: ??Duloxetine oral capsule will be initiated at 60 mg daily. If the score of "severity" or "hot pain" items of neuropathic pain scale does not decrease by 30% after
Sponsors
Kerman University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 75 Years
Inclusion criteria
Inclusion criteria: Burn patients aged 15-75 years
Exclusion criteria
Exclusion criteria: Consuming monoamine oxidase inhibitor drugs, three cyclic antidepressant drugs, selective serotonin reuptake inhibitors, venlafaxine, tramadol, buspirone, triptan drugs, lithium, ondansetron, antiepileptic drugs, linezolid, potent inhibitors of cytochrome P450 (CYP450) 2D6 and CYP450 1A2 Creatinine clearance less than 60 ml per minute Hepatic failure or elevated liver enzymes Epilepsy Depression Bipolar mood disorder Thrombocytopenia Hyponatremia Heart failure Pregnancy Lactation Uncontrolled open angle glaucoma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of background pain. Timepoint: At the initiation of the study and every other day. Method of measurement: Severity item of the neuropathic pain scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of the background pain. Timepoint: At the initiation of the study and every other day. Method of measurement: Other items of the neuropathic pain scale.;Severity of procedural pain. Timepoint: At the initiation of the study and every other day. Method of measurement: Visual analog scale.;Anxiety. Timepoint: At baseline and before each procedure. Method of measurement: Burn Specific Pain Anxiety Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNaemeh Nikvarz
Kerman University of Medical Sciences
Outcome results
None listed