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The effectiveness of DHA serum in the treatment of aluminum phosphide poisoning

Determining the effectiveness of Dihydroxyacetone (DHA) serum in the treatment of patients with aluminum phosphide (rice tablet) poisoning by assessing the blood pressure and ECG changes and cardiac function

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20150606022569N4
Enrollment
10
Registered
2023-10-26
Start date
2023-11-05
Completion date
Unknown
Last updated
2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Poisoning with rice tablets (aluminum phosphide). Toxic effect of rodenticides

Interventions

Intervention group: The dihydroxyacetone (DHA) serum for injection, which is prepared in 500 cc bottles of 5% dextrose water at Shiraz University of Medical Sciences, is given intravenously to the pat

Sponsors

Bojnourd University of Medical Sciences
Lead Sponsor
Shiraz University of Medical Sciences
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: This study is conducted on people who have been poisoned (intentionally or unintentionally) with aluminum phosphide (rice tablets).

Exclusion criteria

Exclusion criteria: The rice tablet(s) is/are exceeded their expiration date. The tablet(s) is/are exposed to moisture and release(s) its/their phosphine gas. The tablet(s) is/are dissolved in water prior to use and so release(s) its/their phosphine gas. The tablet(s) is/are thoroughly crushed before use, resulting in a large amount of phosphine gas being released. The tablet(s) and its/their contents are thrown out immediately after eating due to vomiting. The person ingested the "Banan tablet" (a tablet that contains garlic, salt and starch, and is sometimes erroneously referred to as the rice tablet in Iran).

Design outcomes

Primary

MeasureTime frame
Changes in blood pressure. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Blood pressure monitor.;Electrocardiogram (ECG) changes. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Electrocardiography.;Contractile strength of the heart by measuring EF. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Echocardiography.

Secondary

MeasureTime frame
Arterial oxygen saturation. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Measurement of arterial oxygen saturation.;Blood glucose. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Laboratory measurement of blood glucose.;Level of consciousness. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Using the Glasgow Coma Scale (GCS).;Mortality rate. Timepoint: End of the study. Method of measurement: Number of patients who died.;Incidence of adverse effects. Timepoint: During and following the administration of DHA until the death or hospital discharge. Method of measurement: Incidence of the adverse effect following DHA injection.;Arterial blood acidity. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Measurement of arterial blood pH.;Heart rate. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Heart rate monitor.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Bagher Oghazian

Bojnourd University of Medical Sciences

mohammadbagher_oghazian@yahoo.com+98 58 3151 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026