Comparison effects of Mannitol 20% and Hypertonic Saline 5% on Electrolyte Balance during Brain Tumor Surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015060222535N1

Enrollment

Registered

2015-06-16

Start date

2015-10-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neoplasm of brain. Malignant neoplasm of brain(unspecified)

Interventions

Intervention 1: Mannitol(20%): Dose: 5 ml/kg Number of using: Once Factory name: Razi Manufacturing Country's Name: Iran Location prescribed: Intravenous Injection Administration time: At the begi

Treatment - Drugs

Mannitol(20%): Dose: 5 ml/kg Number of using: Once Factory name: Razi Manufacturing Country's Name: Iran Location prescribed: Intravenous Injection Administration time: At the beginning of t

Hypertonic Saline(5%): Dose: 2.5 ml/kg Number of using: Once Factory name: Alborz Manufacturing Country's Name: Iran Location prescribed: Intravenous Injection Administration time: At the beg

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: - The parent's consent - Age between 18 and 60 years old - ASA class I Exclusion criteria: - Previous complications with general anesthesia - Heart disease - Metabolic disorders - Chronic alcohol consumption - Brain herniation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum Sodium. Timepoint: Before surgery, 120 minutes after the start of surgery and at the end of the surgery. Method of measurement: Laboratory.;Serum Pottasium. Timepoint: before surgery, 120 minutes after the start of surgery and at the end of the surgery. Method of measurement: Laboratory.;Serum Chlorine. Timepoint: Before surgery, 120 minutes after the start of surgery and at the end of the surgery. Method of measurement: Laboratory.;Bicarbonate. Timepoint: Before surgery, 120 minutes after the start of surgery and at the end of the surgery. Method of measurement: Laboratory.	—

Measure

Time frame

Serum Sodium. Timepoint: Before surgery, 120 minutes after the start of surgery and at the end of the surgery. Method of measurement: Laboratory.;Serum Pottasium. Timepoint: before surgery, 120 minutes after the start of surgery and at the end of the surgery. Method of measurement: Laboratory.;Serum Chlorine. Timepoint: Before surgery, 120 minutes after the start of surgery and at the end of the surgery. Method of measurement: Laboratory.;Bicarbonate. Timepoint: Before surgery, 120 minutes after the start of surgery and at the end of the surgery. Method of measurement: Laboratory.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHengameh Rajabzadeh

Ahvaz Jundishapur University of Medical Sciences

Rajabzadeh.h@ajums.ac.ir, fatahi.m@ajums.ac.ir+98 61 1432 5879

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026