A comparison of the effects of 12 weeks walking with two different intensities on the expression of circulating miR-146a, miR-181a and Plasma levels of inflammatory markers IL-6 and TNF-a In Sedentary Aged Women.

A comparison of the effects of 12 weeks walking with two different intensities on the expression of circulating miR-146a and miR-181a and Plasma levels of inflammatory markers IL-6 and TNF-a In Sedentary Aged Women.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

IRCT

Registry ID

IRCT20150531022498N23

Enrollment

Registered

2018-07-06

Start date

2018-04-21

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases associated with aging and inflammation.

Interventions

Intervention 1: The first Intervention group: moderate intensity of walking, In this group, the subjects will be walking(55-50% of the target heart rate) for 12 weeks and 3 sessions in a week. The wor

Eligibility

Sex/Gender

Female

Age

60 Years to 75 Years

Inclusion criteria

Inclusion criteria: Women Age range 60 to 75 Inactive

Exclusion criteria

Exclusion criteria: Having any chronic and inflammatory disease Having any particular diet or medication during the study period Use of auxiliary equipment for walking Motor limitation in the pelvic, hip and knee joints

Design outcomes

Primary

Measure	Time frame
Plasma level of miR-146a. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by polymerase chain reaction (PCR).;Plasma level of microRNA-181a. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by polymerase chain reaction (PCR).;Plasma level of Interleukin-6. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Serum level using ELISA Kit.;Plasma level of Tumor necrosis factor alpha (TNF-a). Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Serum level using ELISA Kit.;White blood cell counts. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using blood sample.	—

Measure

Time frame

Plasma level of miR-146a. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by polymerase chain reaction (PCR).;Plasma level of microRNA-181a. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by polymerase chain reaction (PCR).;Plasma level of Interleukin-6. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Serum level using ELISA Kit.;Plasma level of Tumor necrosis factor alpha (TNF-a). Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Serum level using ELISA Kit.;White blood cell counts. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using blood sample.

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Secondary

Measure	Time frame
Blood pressure variables. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Rest levels using by measurement of systolic blood pressure, diastolic blood pressure and heart rate.;Quality of life. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by quality of life questionnaire (SF-36).;Body composition. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by measurement of weight, body mass index (BMI), fat percent, fat free mass and waist circumference.;Physical fitness. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by measurement of dynamic and static balance and maximum oxygen consumption (VO2max).	—

Measure

Time frame

Blood pressure variables. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Rest levels using by measurement of systolic blood pressure, diastolic blood pressure and heart rate.;Quality of life. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by quality of life questionnaire (SF-36).;Body composition. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by measurement of weight, body mass index (BMI), fat percent, fat free mass and waist circumference.;Physical fitness. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by measurement of dynamic and static balance and maximum oxygen consumption (VO2max).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFateme Falah

Rasam university of Alborz province

fatemefalah1363@gmail.com+98 26 3452 4701

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026