Use of Doxycycline and Povidon Iodine for in treatment of pleural effusion

Comparison of Doxycycline and Povidon Iodine for in treatment of pleural effusion in patients who candidate for pleurodesis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015052918168N3

Enrollment

Registered

2016-04-08

Start date

2015-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pleural effusion. Pleural effusion, not elsewhere classified

Interventions

Intervention 1: In the case group 20 ml povidon Iodine 10% diluted with 50 ml normal saline 0.9% and 10 ml lidocaine 2% and injected to pleural space via chest tube and clamped for one hour. Intervent

Treatment - Drugs

In the case group 20 ml povidon Iodine 10% diluted with 50 ml normal saline 0.9% and 10 ml lidocaine 2% and injected to pleural space via chest tube and clamped for one hour.

In control cases doxycycline 7 mg per kilogram diluted with 50 ml normal saline 0.9% and 10 ml lidocaine 2% and injected to pleural space via chest tube and clamped for one hour.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Candidates for pleurodesis, recurrent or malignant cases . Exclusion criteria: none

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Daily after intervention. Method of measurement: Numeric Pain Rating Scale.	—

Secondary

Measure	Time frame
Empyema. Timepoint: In the 7, 30, 60 and 90 day after intervention. Method of measurement: Examination and assessment.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArmin Hajizadeh

Semnan University of Medical Sciences

mehrdadzahmatkesh@gmail.com+98 23 3343 7821

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 13, 2026