Chronic kidney disease. Chronic kidney disease, stage 5
Conditions
Interventions
Intervention 1: Historical control: no intervention or injection will be done in this group. Intervention 2: Intervention group: Single peripheral injection of autologous mesenchymal stem cells (1,000
Treatment - Drugs
Treatment - Other
Historical control: no intervention or injection will be done in this group.
Intervention group: Single peripheral injection of autologous mesenchymal stem cells (1,000,000/kg). The mesenchymal stem cells will be separated from fat tissue and then the cells will be cultured an
Sponsors
Vice chancellor for research, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients on peritoneal dialysis; Both sexes; Age between 18-70 years; Being on peritoneal dialysis for at least last two years; Having Ultrafiltration failure Exclusion criteria: Patients who cannot come for regular visits; Patients with less than 1 year survival; Patients on immunosuppressive medications; Pregnancy; Malignancy; Coagulative disorders
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Glomerular filtration rate (GFR). Timepoint: Before and at week 3, week 6, month 3, month 4 and month 6. Method of measurement: MDRD formula.;Kt/V urea. Timepoint: Before and at week 3, week 6, month 3, month 4 and month 6. Method of measurement: Dialyzer clearance of urea * dialysis time/ volume of distribution of urea. | — |
Primary
| Measure | Time frame |
|---|---|
| D/P cr. Timepoint: Before and at week 3, week 6, month 3, month 4 and month 6. Method of measurement: Ratio of 4-hour dialysate/plasma creatinine.;D/P urea. Timepoint: Before and at week 3, week 6, month 3, month 4 and month 6. Method of measurement: Ratio of 4-hour dialysate/plasma urea.;D0/D glucose. Timepoint: Before and at week 3, week 6, month 3, month 4 and month 6. Method of measurement: Ratio of dialysate glucose concentrations at end and at start of tests.;Peritoneal Equilibration Test (PET). Timepoint: Before and at week 3, week 6, month 3, month 4 and month 6. Method of measurement: Assessment of peritoneal membrane transport function by machine. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Sudabeh Alatab
Urology Research Center,Tehran University of Meical Scienses
Outcome results
None listed