brain tumor related epilepsy. Epilepsy
Conditions
Interventions
Intervention 1: Intervention group 1: Levetiracetam starting dose is 250 mg BID and it is up titrated (500 mg/week) to 1.000– 3.000 mg/day, depending on seizure control and tolerability. Intervention
Treatment - Drugs
Intervention group 1: Levetiracetam starting dose is 250 mg BID and it is up titrated (500 mg/week) to 1.000– 3.000 mg/day, depending on seizure control and tolerability.
Intervention group 2: Sodium-valproate starting dose is 200 mg BID, and it is up titrate (200 mg/week) to 1000 – 3000 mg/day, depending on seizure control and tolerability.
Sponsors
Vice chancellor for research of Isfahan University of medical sciences
Cobel Darou company
Eligibility
Sex/Gender
All
Age
12 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients with brain tumors and epilepsy characterized by simple or complex partial seizures, with or without secondary generalization; Patients who had at least one seizure prior to having been referred to our center, who had never undergone prior anti-epileptic drug (AED) therapy; Patients who had received previous AED (with a verification that the previous AEDs had been in the therapeutic range but not controlled; Patients with severe side effects with previous AED therapy. Exclusion criteria: Patients with epilepsy prior to tumor onset; Patient with known sever liver disease for Sodium-Valproate group.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seizure. Timepoint: nomber of seizure attack. Method of measurement: telephon call or visit of patient 0 and 6 month after add patients.;Quality of life. Timepoint: Start of the study and 6 months after the start point. Method of measurement: quality of life in epilepsy inventory (QOLIE-31-P).;Anxiety. Timepoint: Start of the study and 6 months after the start point. Method of measurement: Beck anxiety inventory (BAI).;Depression. Timepoint: Start of the study and 6 months after the start point. Method of measurement: Beck depression inventory (BDI-II).;Cognitive function. Timepoint: Start of the study and 6 months after the start point. Method of measurement: mini-mental state examination (MMSE).;Blood indices. Timepoint: Start of the study and 6 months after the start point. Method of measurement: Taking blood sample and send to laboratory.;Side effects. Timepoint: Monthly. Method of measurement: Interview (in-person and by telephone). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSomayyeh Sadat Teimouri
Isfahan University of Medical Sciences
Outcome results
None listed