Pain management in patients with limb fractures

Efficacy and safety of morphine-ketamine combination in comparison with morphine alone in acute pain management among patients who admitted to emergency with limb fracture

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015052015620N5

Enrollment

192

Registered

2015-08-17

Start date

2012-12-28

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Upper limb injuries. Condition 2: Lower limb injuries. Condition 3: Pain in limb. Fracture of upper end of humerus, Fracture of shaft of humerus, Fracture of lower end of humerus, Fracture of shaft of ulna, Fracture of shaft of radius, Fracture of other parts of forearm Fracture of neck of femur, Fracture of shaft of femur, Fractures of other parts of femur, Fracture of upper end of tibia, Fracture of shaft of tibia, Fracture of fibula alone, Fractures of other parts of lower leg

Interventions

Intervention 1: In the case of Numerical Rating Score equal or greater than 4, 0.1mg/kg bolus dose of morphine prescribe. All the variables such as vital signs, side effects, pain scores will check a

Treatment - Drugs

In the case of Numerical Rating Score equal or greater than 4, 0.1mg/kg bolus dose of morphine prescribe. All the variables such as vital signs, side effects, pain scores will check at consequent fif

In the case of Numerical Rating Score equal or greater than 4, 0.1mg/kg bolus dose of morphine prescribe. All the variables such as vital signs, side effects, pain scores will check at consequent fi

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age between 18 and 50 years, patients with Limbs trauma, Acute pain, confirmed limb fractures with imaging. Exclusion criteria: cases with opium addiction, any analgesic drug consumption prior coming to ED, pregnant women, any allergy to Ketamine or Morphine, history of chronic pain, asthma, renal failure, coronary disease, and unstable hemodynamic status were excluded.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Age, Gender, Blood Pressure, Respiratory Rate, Numerical Rating Scale, Pulse Rate, Fracture Type. Timepoint: Fifth, tenth, 20th Minutes after each drug administration. Method of measurement: Questionnaire.	—

Secondary

Measure	Time frame
Drug side effects. Timepoint: Fifth, tenth, 20th Minutes after each drug administration. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZein Alabedin Chaboksavar

Shahid Beheshti University of Medical Sciences

Zchaboksavar@Yahoo.com+98 26 3286 1602

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026