Effects of adding different doses of epinephrine to the fentanyl and bupivacaine solution in spinal anesthesia in lower limb orthopedic surgeries with torniquet

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201505193829N5

Enrollment

Registered

2016-02-16

Start date

2015-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal anesthesia in lower limb orthopedic surgeries. M22, M23

Interventions

Intervention 1: Group A : 0.1 mg Epinephrine + 25 microgram Fentanyl + 12-15 mg Bupivacaine.(According Methods) Fentanyl: Darou Pakhsh Company Bupivacaine: Aburaihan Company Epinephrine: Darou Pakhs

Treatment - Drugs

Group A : 0.1 mg Epinephrine + 25 microgram Fentanyl + 12-15 mg Bupivacaine.(According Methods) Fentanyl: Darou Pakhsh Company Bupivacaine: Aburaihan Company Epinephrine: Darou Pakhsh Company

Group B : 0.3 mg Epinephrine + 25 microgram Fentanyl + 12-15 mg Bupivacaine.(According Methods) Fentanyl: Darou Pakhsh Company Bupivacaine: Aburaihan Company Epinephrine: Darou Pakhsh Company

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: candidates of lower limb orthopedic surgeries with torniquet with ASA class I and II; ages between 20-65 Exclusion criteria: emergency surgeries;patient dissatisfaction; infection of injection site; high intracranial pressure; coagulopathy; difficulties to communicate with patient in order to evaluate them during surgery; addiction; allergies to spinal anesthetic drugs

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Sensory Block. Timepoint: After spinal up to reaching to the highest sensory block level and 4 dermatome backsliding. Method of measurement: Pinprick method.;Motor Block. Timepoint: After spinal up to complete motor block, 10, 20, 30, 60, 90, 120 minutes after spinal. Method of measurement: Bromage scale.	—

Secondary

Measure	Time frame
Atropin. Timepoint: During Surgery. Method of measurement: Usage dose (milligram).;Ephedrin. Timepoint: During Surgery. Method of measurement: Usage dose (milligram).;Nausea and Vomiting. Timepoint: During and After Surgery. Method of measurement: Observation-Yes/No.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNegin Saeedi

Sina Hospital

n-saeedi@alumnus.tums.ac.ir+98 21 6634 8533

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026