Effect of finastride on TUR-P blood loss

To investigate the effect of 5mg daily oral finasteride 7 and 14 days before TUR-P on tissue expression of VEGF, MVD and peri-operative and post-operative blood loss in comparison to placebo

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015050922168N1

Enrollment

Registered

2015-06-10

Start date

2015-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

BPH. Hyperplasia of prostate

Interventions

Intervention 1: First intervention group will receive 5 mg daily oral finastride from week before the surgery. Intervention 2: Second intervention group will receive 5 mg daily oral finastride from tw

Treatment - Drugs

First intervention group will receive 5 mg daily oral finastride from week before the surgery

Second intervention group will receive 5 mg daily oral finastride from two weeks before the surgery

Control group will recieve placebo from two weeks before the surgery

Eligibility

Sex/Gender

Male

Age

40 Years to 90 Years

Inclusion criteria

Inclusion criteria: BPH patients who are candidate for TUR-P due to obstructive urinary symptoms

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hematocrit. Timepoint: Just before the surgery and 6 hours after. Method of measurement: %.;Tissue microvascular density. Timepoint: After TURP. Method of measurement: The average number of vessels counted in 10 non-overlapping hpf.;Tissue Vascular endothelial growth factor. Timepoint: After TURP. Method of measurement: The average tissue expression of VEGF in specimens.;Surgens satisfaction. Timepoint: After TURP. Method of measurement: based on visual analog scale- 0 to 10.;Removed tissue weight. Timepoint: After TURP. Method of measurement: weight of removed tissue by TURP in gram.;Percent of tissue removed by TURP. Timepoint: After TURP. Method of measurement: weight of tissue removed by TURP devided by total prostate weight.;Total operative time. Timepoint: after TURP. Method of measurement: time from starting TURP until foley fixation- in minutes.	—

Measure

Time frame

Hematocrit. Timepoint: Just before the surgery and 6 hours after. Method of measurement: %.;Tissue microvascular density. Timepoint: After TURP. Method of measurement: The average number of vessels counted in 10 non-overlapping hpf.;Tissue Vascular endothelial growth factor. Timepoint: After TURP. Method of measurement: The average tissue expression of VEGF in specimens.;Surgens satisfaction. Timepoint: After TURP. Method of measurement: based on visual analog scale- 0 to 10.;Removed tissue weight. Timepoint: After TURP. Method of measurement: weight of removed tissue by TURP in gram.;Percent of tissue removed by TURP. Timepoint: After TURP. Method of measurement: weight of tissue removed by TURP devided by total prostate weight.;Total operative time. Timepoint: after TURP. Method of measurement: time from starting TURP until foley fixation- in minutes.

—

Secondary

Measure	Time frame
Short term complications. Timepoint: one week after TURP. Method of measurement: complications that will happen within a week after the surgery.;Long term complications. Timepoint: After one week following TURP. Method of measurement: complications that happens after a week within 3 months after TURP.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Dinyar Khazaeli

Ahvaz Jundishapur University of Medical Sciences

khazaeli_dinyar@yahoo.com dinyar.khazaeli@gmail.com khazaeli-d@ajums.ac.ir+98 61 3222 2114

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026