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Carbetocin versus Oxytocin for prevention of postpartum hemorrhage at cesarean section

Comparison between effects of Carbetocine and Syntometrin on postpartum hemorrhage prevention after cesarean section

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015050919644N1
Enrollment
90
Registered
2015-05-09
Start date
2015-03-06
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postpartum hemorrhage. Postpartum care and examination

Interventions

Intervention 1: 30 unite Syntometrine in 1 liter crystaloid 10cc /min after clamp of umbilical cord then 30 unite in 8 hours ,20 unite in 8 hours & then 10 unite in 8 hours later Syntometrine IV inf
Prevention
30 unite Syntometrine in 1 liter crystaloid 10cc /min after clamp of umbilical cord then 30 unite in 8 hours ,20 unite in 8 hours & then 10 unite in 8 hours later Syntometrine IV infusion
0.5 ml Carbetocin IV directly Equivalent 50 micro gram once after clamp of umbilical cord

Sponsors

Vice Chancellor for research, Zahedan University of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: Pregnant women with single pregnancy one previous cesarean section or primary cesarean and candidate for cesarean delivery & application of spinal anesthesia. 5- Exclusion criteria: Other reason of PPH except atonia; Presence of preeclampsia; hypotension; heart disease and asthma; Presence of risk factor of PPH such as uterine fibroid? previous myomectomy? placenta previa? past history of PPH? chorioamnionitis; fetal macrosomia and fetal malformations associated with polyhydramnios

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Hemoglobin level. Timepoint: Before and 6 and 12hours after cesarean delivery. Method of measurement: Hemoglobine assessment.

Secondary

MeasureTime frame
Uterine tone. Timepoint: 2 and 12 and 24 hours after cesarean delivery. Method of measurement: Assessment of uterine tone.;Need to adminestration of utertonic drug. Timepoint: During 24 hours after cesarean delivery. Method of measurement: Dosage and amount of drug.;Adverse effects. Timepoint: During 24 hours after cesarean delivery. Method of measurement: Observation of adverse effects.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Seyede Fatemeh Mahdavi Salimi

Emam Ali hospital

drf_mahdavi@yahoo.com+98 54332955759

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026