Evaluation of the effect of Melatonin on prevention of postpartum bleeding

Comparison of the effect of using and not using of melatonin on prevention of patients' postpartum uterus bleeding after normal vaginal delivery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015050919037N9

Enrollment

140

Registered

2015-06-01

Start date

2014-12-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum haemorrhage. haemorrhage after delivery of fetus or infant

Interventions

Intervention 1: Group 1 (control): Only the usage of needed dosage of Oxytocin intravenous fluid (common and standard treatment) for prevention of postpartum hemorrhage. Intervention 2: Group 2 (inter

Prevention

Group 1 (control): Only the usage of needed dosage of Oxytocin intravenous fluid (common and standard treatment) for prevention of postpartum hemorrhage

Group 2 (intervention): Receive 3 doses of Melatonin sublingually: 6 mg at 7 cm dilatation, 3 mg after fetus exit and 3 mg 1 hour after delivery. (Tablet Melatonin 3 mg from NatureMade company, The U

Eligibility

Sex/Gender

Female

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Term pregnant women with simultaneous labor pain and hemoglobin level above 10 mg/dl. Exclusion criteria: History of underline disease, dystocia, multiparity, chorioamnionitis and need for delivery induction, cesarean section or blood transfusion.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum hemoglobin level. Timepoint: Until 24 hours after delivery (every 6 hours). Method of measurement: Blood sampling test.;Serum hematocrit level. Timepoint: Until 24 hours after delivery (every 6 hours). Method of measurement: Blood sampling test.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: Until 6 hours after delivery, every 2 hours. Method of measurement: Monitor device.;Heart rate. Timepoint: Until 6 hours after delivery, every 2 hours. Method of measurement: Monitor device.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mahour Kamali

Kosar Obstetrics and Gynecology Hospital

dr.kamali82@yahoo.com+98 28 3323 6374

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026