contrast-induced nephropathy and the patient’s undergone coronary angiography

Comparison of N-acetylcysteine, Ascorbic acid and Normal saline effect in prevention of contrast-induced nephropathy on the patient’s undergone coronary angiography

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015050722134N1

Enrollment

120

Registered

2015-06-16

Start date

2014-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Acute nephritic syndrome. Condition 2: Heart failure. Left ventricular failure

Interventions

Intervention 1: group A:N-acetylcysteine ( NAC)(600mg/BID) plus normal saline (100ml/hour).for 72hours. Intervention 2: group B: ascorbic acid (250 mg/BID) plus normal saline (100ml/hour). for 72 hou

Treatment - Drugs

group A:N-acetylcysteine ( NAC)(600mg/BID) plus normal saline (100ml/hour).for 72hours

group B: ascorbic acid (250 mg/BID) plus normal saline (100ml/hour). for 72 hours

group C :normal saline (100ml/hour). for 72 hours

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: creatinine level of >1.5mg/dl; glomerular filtration rate ( GFR) = 60 Exclusion criteria: Oliguria (<400cc/24hours); severe heart failure with left ventricular ejection fraction (LVEF) < 35%; contrast-agent hypersensitivity; pregnancy; lactation; acute renal failure; Vitamin C supplements

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Creatinine. Timepoint: before and after angiography. Method of measurement: ELISA kit.;Glomerular filtration. Timepoint: before and after angiography. Method of measurement: Were used average estimated glomerular filtration rate of clearance of endogenous or exogenous materials.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmrollah Ebrahimi

Isfahan University of Medical Sciences

a_ev11@yahoo.com+98 913 117 1521

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026