The effect of cardamom supplementation on blood oxidative stress status and inflammatory factors in prediabetic women

The effect of cardamom supplementation on blood oxidative stress status and inflammatory factors in overweight and obese prediabetic women

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015042917254N3

Enrollment

Registered

2015-05-09

Start date

2013-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pre diabetes. Impaired glucose tolerance Prediabetes

Interventions

Intervention 1: group receiving green cardamom :capsules containing 1g cardamom, three a day for 2 month. Intervention 2: placebo group receiving rusk powder: capsules containing 1g of rusk powder, th

Placebo

group receiving green cardamom :capsules containing 1g cardamom, three a day for 2 month

placebo group receiving rusk powder: capsules containing 1g of rusk powder, three a day for 2 month

Eligibility

Sex/Gender

Female

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Prediabetic women with one of the following criteria: FBS; 100-125 mg/dl, HbA1C: 5.7-6.4, 2hpp blood glucose: 140-199 mg/dl; Age: 30-70 years; BMI: 25-39.9 kg/m2; Having at least one of the following criteria: TG>150 mg/dl, Chol>200 mg/dl, LDL>100 mg/dl, HDL130/80 mmHg; LDL>160 mg/dl; TG>300 mg/dl; Smoking. Exclusion criteria: Multi vitamin and anti oxidant supplements consumption during the intervention; Changes in diet or physical activity; Not intaking of more than 10% of supplements; Morbidity to diabetes during the intervention.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
GR activity. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting GR activity by using kits.;SOD activity. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting SOD activity by using kits.;Serum Total Antioxidant Capacity. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of Serum Total Antioxidant Capacity by using kits.;MDA Concentration. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting MDA Concentration by using kits.;Protein Carbonyl Concentration. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting Protein Carbonyl Concentration by using kits.;IL-6 Concentration. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting IL-6 Concentration by using kits.;Hs-CRP Concentration. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting hs-CRP Concentration by using kits.;TNF-a Concentration. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting TNF-a Concentration by using kits.	—

Measure

Time frame

GR activity. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting GR activity by using kits.;SOD activity. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting SOD activity by using kits.;Serum Total Antioxidant Capacity. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of Serum Total Antioxidant Capacity by using kits.;MDA Concentration. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting MDA Concentration by using kits.;Protein Carbonyl Concentration. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting Protein Carbonyl Concentration by using kits.;IL-6 Concentration. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting IL-6 Concentration by using kits.;Hs-CRP Concentration. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting hs-CRP Concentration by using kits.;TNF-a Concentration. Timepoint: before and after the intervention. Method of measurement: Enzymatic Measurement of fasting TNF-a Concentration by using kits.

—

Secondary

Measure	Time frame
Waist circumference. Timepoint: before and after the intervention. Method of measurement: measurement with a meter.;BMI. Timepoint: before and after the intervention. Method of measurement: Measured with formula.;Weight. Timepoint: before and after the intervention. Method of measurement: Measured with a digital scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Yaghooblou

Tehran university of Medical Sciences

yaghooblou.fatemeh@yahoo.com+98 26 3451 4381

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026