An assessment about the effect of Pregabaline(75 mg) or Deuloxetin(30 mg) on pain relief in CPD due to Endometriosis

Comparison between the effect of oral Pregabalin (75 mg) and Deuloxetin (30mg) with Amitryptilin) on decreasing chronic pelvic pain due to Endometriosis

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015042916325N2

Enrollment

100

Registered

2015-06-26

Start date

2016-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory disease of uterus, except cervix. Chronic inflammatory disease of uterus

Interventions

Intervention 1: Pregabalin 75 mg + Amitryptiline 10 mg. Intervention 2: Duloxetin 30 mg + Amitryptiline 10 mg.

Treatment - Drugs

Pregabalin 75 mg + Amitryptiline 10 mg

Duloxetin 30 mg + Amitryptiline 10 mg

Eligibility

Sex/Gender

Female

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Known case of Endometriosis according to pathology or radiology; Pelvic pain more than 6 month; Age between 18 and 60 years old; Comprehension and sign the consent inform. Exclusion Criteria: Previous surgery; Need to strong opioids; coexisting pelvic disorders; History of urinary tract infection,IBS, IBD, and cancer; Pregnancy and breast feeding; Psychiatric disorders(Minor and Major Depression, suicide, Bipolar disorders; Epilepsy; Hypertension; Hypersensitivity to drugs; MAOI consumption; Closed angle Glocoma; Renal Disorders; History of Juindice or hepatic disorders; Consumption of MAOI, SMRIs, SSRIs 2 weeks ago; Alcohol consumption; Hyponatremia; Weight gain>285 Pound

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain Score of Chronic pelvic pain due to Endometriosis. Timepoint: 2 weeks, 1 month, and 3 months after receiving the first dose of drug. Method of measurement: Numerical Rating Scale(NRS).	—

Secondary

Measure	Time frame
Severity of Chronic pelvic pain due to Endometriosis. Timepoint: 2 weeks, 1 month, and 3 months after receiving the first dose of drug. Method of measurement: With the question: How much do you experience pain relief after receiving treatment from our center? (0-100%).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKatayoun Haryalchi

Guilan University of Medical Sciences

k_haryalchi@yahoo.com+98 133228724

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026