infertility. female infertility
Conditions
Interventions
Intervention 1: Intervention group: Oral melatonin tablet is administered to 45 women undergoing IVF as an intervention group. Daily melatonin dosage is 3 mg orally (nature made,USA) taken at 22:00 pm
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Age 18-40 yrs.; normal level of serum steroidal hormones; agonist long protocol of controlled ovarian stimulation; male factor; tubal factor; and unexplained infertility.
Exclusion criteria
Exclusion criteria: Myoma; a congenital uterine anomaly; use of estrogens; progesterone; androgens; or chronic use of any medication; including nonsteroidal anti-inflammatory agents or anticonvulsants, smoking; severe endometriosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The degenerate oocyte counts. Timepoint: oocyte pick up day. Method of measurement: Microscopic assay.;The fertilization rate. Timepoint: 24 hours after ICSI. Method of measurement: Microscopic assay.;The embryo quality. Timepoint: 24 hours after ICSI. Method of measurement: Microscopic assay.;The mean number of the oocytes. Timepoint: oocyte pick up day. Method of measurement: Microscopic assay.;The mean metaphase II (MII) oocyte counts. Timepoint: oocyte pick up day. Method of measurement: Microscopic assay. | — |
Secondary
| Measure | Time frame |
|---|---|
| MRNA level of MT-ATP6 gene incumulus cells. Timepoint: after sampling. Method of measurement: q-PCR.;The biochemical pregnancy rate. Timepoint: 2 weeks after embryo transfer. Method of measurement: ??Serum B.hCG titter. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Sadat Hoseini
Tehran University of Medical Sciences
Outcome results
None listed