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Olfactory stimulation on apnea of prematurity

The effect of olfactory stimulation by vanillin on the range of apneal attacks in newborns affected by apnea of prematurity

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015042821982N1
Enrollment
40
Registered
2016-07-05
Start date
2016-07-05
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

apnea. Other apnoea of newborn

Interventions

Intervention 1: Iintervention group: use 2 cc of liquid vanilla 64% within the incubator babies at a distance of 20 cm from the head and without skin contact. Intervention 2: Control group: Use 2 ml o
Prevention
Iintervention group: use 2 cc of liquid vanilla 64% within the incubator babies at a distance of 20 cm from the head and without skin contact.
Control group: Use 2 ml of distilled water at a distance of 20 cm from the head and without skin contact

Sponsors

Vice Chancellor for research of Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Days to 28 Days

Inclusion criteria

Inclusion criteria: Inclusion criteria: Babies less than 32 weeks with weight less than 32 weeks who developed immature apnea and specialists distinguish immature apnea and started Methyl Xanthine for treatment and also 4-8 hours after receiving Methyl Xanthine are started into the study. Exclusion criteria: Distinguished apnea due to other reasons including acute infections; congenital heart illnesses; anemia (Hb<10); consumers of sedative medicines; hypoglycemia; hypocalcaemia are removed and babies with brain hemorrhage than grade 1; leukomalacia preventricular; patent dactus arterious; chromosomal disorders; brain disorders and babies with allergy to vanilla smell are not introduced into the study. During the study, babies with Hemoglobin less than 10 and babies with apnea more than 3 are connected to cpap within one hour and are out of the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Oxygen saturation. Timepoint: First, second and third day after birth in both control and experimental groups. Method of measurement: As percentage using a pulse oximeter.;Heart rate. Timepoint: First, second and third day after birth in both control and experimental groups. Method of measurement: as beat using pulse oximetry.;Episods of apnea. Timepoint: First, second and third day after birth in both control and experimental groups. Method of measurement: as beat using pulse oximetry.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNayer Salmani

Yazd University of Medical Sciences

n.salmani@sbmu.ac.ir+98 35 3824 1751

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026